Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.72 |
| ▸ | PIM1 | P11309 | 1/20 | 0.72 |
| ▸ | CLK2 | P49760 | 1/20 | 0.72 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.72 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.72 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.72 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.72 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.72 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.72 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | PARP1 | P09874 | 11/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.52 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587286 | 0.84 | AURKA (0.76) | AURKBAURKAPARP1PARP2PLA2G2A | |
| SCHEMBL3575168 | 0.84 | SIRT2 (0.52) | AURKBPRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL3581187 | 0.84 | AURKB (0.64) | AURKBPRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL6948231 | 0.81 | PARP1 (0.69) | AURKBPRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL3577220 | 0.81 | AURKA (0.71) | AURKBAURKAPARP1PARP2PLA2G2A | |
| SCHEMBL6810422 | 0.80 | PKN1 (0.76) | AURKBPRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL7822007 | 0.79 | MGAM (0.59) | AURKBAURKAPARP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3577852 | 0.79 | AURKB (0.61) | AURKBPRKD3MAP4K4PIM1CLK2 | |
| SCHEMBL3582276 | 0.78 | AURKB (0.82) | AURKBAURKAPARP1PARP2PLA2G2A | |
| SCHEMBL6581295 | 0.78 | AURKB (0.56) | AURKBPRKD3MAP4K4PIM1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |