Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.61 |
| ▸ | PIM1 | P11309 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.61 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.61 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.61 |
| ▸ | PARP1 | P09874 | 7/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583754 | 0.85 | KDM4E (0.47) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL3577856 | 0.84 | KDM4E (0.50) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL3575386 | 0.83 | PARP1 (0.67) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL6810422 | 0.83 | PKN1 (0.76) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL3585590 | 0.83 | PKN1 (0.54) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL6948231 | 0.81 | PARP1 (0.69) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL3575162 | 0.79 | AURKB (0.72) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL7480831 | 0.78 | PKN1 (0.67) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL6578697 | 0.77 | HPSE (0.47) | AURKBMAP4K4PIM1CLK2DYRK1A | |
| SCHEMBL3580402 | 0.76 | PARP1 (0.69) | AURKBMAP4K4PIM1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |