Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 11/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 11/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867984 | 0.75 | HSD17B10 (0.46) | KDM4EKMT2ARAB9AHSD17B10ALDH1A1 | |
| SCHEMBL3866299 | 0.74 | HSD17B10 (0.44) | KDM4EKMT2AHSD17B10ALDH1A1MEN1 | |
| SCHEMBL3569292 | 0.72 | KDM4E (0.58) | KDM4EKMT2AHSD17B10ALDH1A1HPGD | |
| SCHEMBL28346334 | 0.72 | NOTUM (0.52) | NOTUMKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL3574329 | 0.71 | HSD17B10 (0.42) | GSK3BKDM4ENPC1RAB9AHSD17B10 | |
| SCHEMBL3571739 | 0.70 | KDM4E (0.43) | KDM4ENPC1HSD17B10ALDH1A1HPGD | |
| SCHEMBL28346359 | 0.70 | NOTUM (0.49) | NOTUMKDM4EKMT2ANPC1RAB9A | |
| SCHEMBL3443882 | 0.69 | KDM4E (0.43) | GSK3BKDM4EKMT2ARAB9AALDH1A1 | |
| SCHEMBL1337392 | 0.68 | HSD17B10 (0.46) | KDM4EKMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL1336997 | 0.68 | MAPK14 (0.49) | KDM4EKMT2AHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812165-B2 | 6-substituted pyridoindolone derivatives, production and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-10-12 | — | — | US | disclosed |
| US-20070129365-A1 | 6-Substituted pyridoindolone derivatives, production and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129365-A1 | 6-Substituted pyridoindolone derivatives, production and therapeutic use thereof | PNPO, CYP2D6, DPYD | NOTUM 4010/4885GSK3B 1819/4885PIM1 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.