Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | BRD2 | P25440 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.47 |
| ▸ | MARK3 | P27448 | 2/20 | 0.46 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.44 |
| ▸ | CDK2 | P24941 | 9/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.44 |
| ▸ | CDK9 | P50750 | 7/20 | 0.44 |
| ▸ | CDK1 | P06493 | 6/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.44 |
| ▸ | CDK7 | P50613 | 6/20 | 0.44 |
| ▸ | CCNH | P51946 | 6/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586598 | 0.90 | CDK4 (0.55) | CDK4CDK6CCNA2CDK2CDK1 | |
| SCHEMBL3584293 | 0.90 | CDK4 (0.55) | CDK4CDK6CCNA2CDK2CDK1 | |
| SCHEMBL3592565 | 0.90 | CDK4 (0.55) | CDK4CDK6CCNA2CDK2CDK1 | |
| SCHEMBL3577561 | 0.80 | CDK4 (0.57) | CDK4CDK6JAK2JAK1JAK3 | |
| SCHEMBL3590043 | 0.80 | CDK4 (0.57) | CDK4CDK6JAK2JAK1JAK3 | |
| SCHEMBL3579088 | 0.80 | CDK4 (0.52) | CDK4CDK6JAK2CCNA2CDK2 | |
| SCHEMBL3577564 | 0.80 | CDK4 (0.57) | CDK4CDK6JAK2JAK1JAK3 | |
| SCHEMBL3579086 | 0.80 | CDK4 (0.52) | CDK4CDK6JAK2CCNA2CDK2 | |
| SCHEMBL3583817 | 0.80 | CDK4 (0.52) | CDK4CDK6JAK2CCNA2CDK2 | |
| SCHEMBL3587338 | 0.77 | MARK3 (0.42) | CDK4CDK6MARK3MARK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | CDK4 102/4885CDK6 64/4885JAK2 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.