Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581919 | 0.90 | AURKB (0.64) | PARP1DHODHAURKBKDRPKN1 | |
| SCHEMBL6581306 | 0.85 | PARP1 (0.41) | PARP1DHODHAURKBKDRPKN1 | |
| SCHEMBL3580135 | 0.84 | AURKB (0.61) | PARP1DHODHAURKBKDRPKN1 | |
| SCHEMBL3576439 | 0.84 | KDR (0.38) | PARP1DHODHAURKBKDRPKN1 | |
| SCHEMBL3165557 | 0.78 | PARP1 (0.74) | PARP1DHODHAURKBPKN1PKN2 | |
| SCHEMBL13225614 | 0.78 | PARP1 (0.62) | PARP1DHODHAURKBKDRPKN2 | |
| SCHEMBL3255801 | 0.78 | PARP1 (0.73) | PARP1DHODHAURKBPKN1PKN2 | |
| SCHEMBL3586249 | 0.77 | KDR (0.54) | PARP1DHODHAURKBKDR | |
| SCHEMBL3260128 | 0.77 | PARP1 (0.76) | PARP1DHODHAURKBPKN1PKN2 | |
| SCHEMBL6582945 | 0.75 | AURKB (0.47) | PARP1DHODHAURKBKDRPKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |