Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580135 | 0.85 | AURKB (0.61) | PARP1AURKBKDRDHODHDYRK3 | |
| SCHEMBL3586249 | 0.79 | KDR (0.54) | PARP1AURKBKDRDHODH | |
| SCHEMBL3576435 | 0.78 | PARP1 (0.58) | PARP1AURKBKDRDHODHDYRK3 | |
| SCHEMBL7134234 | 0.77 | PARP1 (1.00) | PARP1AURKBDHODHDYRK3MAP4K4 | |
| SCHEMBL3582141 | 0.76 | AURKB (0.75) | PARP1AURKBKDRDHODHDYRK3 | |
| SCHEMBL3578622 | 0.76 | AURKB (0.85) | PARP1AURKBKDRDHODH | |
| SCHEMBL7137094 | 0.74 | PARP1 (0.80) | PARP1AURKBDHODHDYRK3MAP4K4 | |
| SCHEMBL7138597 | 0.74 | PARP1 (0.80) | PARP1AURKBKDRDHODHDYRK3 | |
| SCHEMBL458836 | 0.73 | PARP1 (1.00) | PARP1AURKBDHODHDYRK3MAP4K4 | |
| SCHEMBL29412034 | 0.73 | PARP1 (1.00) | PARP1AURKBDHODHDYRK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |