Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570210 | 0.95 | FFAR1 (0.46) | FFAR1FFAR4SLC2A1LRRK2MAOB | |
| SCHEMBL3574032 | 0.92 | FFAR1 (0.41) | FFAR1FFAR4SLC2A1LRRK2MAOB | |
| SCHEMBL3581565 | 0.88 | SLC2A1 (0.43) | FFAR1FFAR4SLC2A1MAOBPDGFRA | |
| SCHEMBL3575570 | 0.88 | TRPV1 (0.42) | SLC2A1CYP3A4KMT2ALPAR1LPAR5 | |
| SCHEMBL3585679 | 0.88 | LMNA (0.44) | SLC2A1S1PR1S1PR5CYP3A4KMT2A | |
| SCHEMBL3576064 | 0.88 | LMNA (0.46) | FFAR1FFAR4SLC2A1MAOBPDGFRA | |
| SCHEMBL3579168 | 0.87 | SLC2A1 (0.41) | SLC2A1CYP3A4KMT2ALPAR1LPAR5 | |
| SCHEMBL3576819 | 0.87 | SLC2A1 (0.41) | FFAR1FFAR4SLC2A1MAOBPDGFRA | |
| SCHEMBL3584461 | 0.86 | LMNA (0.44) | SLC2A1S1PR1S1PR5CYP3A4KMT2A | |
| SCHEMBL3573413 | 0.86 | LMNA (0.44) | SLC2A1CYP3A4MAPTKMT2ALPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |