Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 6/20 | 0.49 |
| ▸ | GART | P22102 | 1/20 | 0.49 |
| ▸ | ATIC | P31939 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798975 | 0.94 | TYMS (0.85) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL13659931 | 0.94 | TYMS (0.74) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL29385035 | 0.94 | TYMS (0.85) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL1230170 | 0.94 | TYMS (0.85) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL30812371 | 0.93 | TYMS (0.83) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL28961172 | 0.93 | TYMS (0.83) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Calcium SCHEMBL29393226 | 0.93 | TYMS (0.83) | TYMSKDM4EMEN1ALDH1A1POLB | |
| Magnesium SCHEMBL30812372 | 0.93 | TYMS (0.83) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL7604785 | 0.92 | TYMS (0.66) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL2274610 | 0.92 | TYMS (0.72) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150514-B1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2018-10-24 | — | — | EP | disclosed |
| US-9771368-B2 | 18F-labelled folates | Merck & Cie (CH) | 2017-09-26 | — | — | US | disclosed |
| US-20160159802-A1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2016-06-09 | — | — | US | disclosed |
| US-9315506-B2 | 18F-labelled folates | Merck & Cie (CH) | 2016-04-19 | — | — | US | disclosed |
| US-20100056533-A1 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2010-03-04 | — | — | US | disclosed |
| EP-2150514-A2 | 18F-LABELLED FOLATES | Merck Eprova AG (CH) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008125617-A2 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056533-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | TYMS 12/4885KDM4E 2138/4885MEN1 1078/4885 |
| US-20160159802-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | TYMS 14/4885KDM4E 2434/4885MEN1 992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.