Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15209096 | 0.84 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL2373838 | 0.83 | KDM4E (0.62) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL9410482 | 0.82 | KDM4E (0.66) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL8307320 | 0.82 | KDM4E (0.61) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL3056019 | 0.81 | KDM4E (0.46) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL27995184 | 0.79 | KDM4E (0.44) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL9151554 | 0.78 | SMN1; SMN2 (0.48) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL8310828 | 0.76 | KDM4E (0.58) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL18382969 | 0.75 | KDM4E (0.41) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL9043817 | 0.75 | LMNA (0.45) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952842-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-11-03 | — | — | EP | claimed |
| WO-1997038664-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | claimed |
| JP-9100277-A | — | — | None | — | — | JP | disclosed |
| CN-110818637-B | Substituted amide compound and preparation method and application thereof | 山东省联合农药工业有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-110818637-A | Substituted amide compound and preparation method and application thereof | 山东省联合农药工业有限公司 | 2020-02-21 | — | — | CN | disclosed |
| US-10556888-B2 | Pyrazole compounds or salts thereof, preparation methods therefor, herbicidal compositions and use thereof | QINGDAO KINGAGROOT CHEMICAL COMPOUNDS CO., LTD. (CN) | 2020-02-11 | — | — | US | disclosed |
| US-20180105513-A1 | PYRAZOLE COMPOUNDS OR SALTS THEREOF, PREPARATION METHODS THEREFOR, HERBICIDAL COMPOSITIONS AND USE THEREOF | QINGDAO KINGAGROOT CHEMICAL COMPOUNDS CO., LTD. (CN) | 2018-04-19 | — | — | US | disclosed |
| US-9856240-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| EP-2636669-B1 | PYRAZOLE AMIDE COMPOUND AND USE THEREOF AS FUNGICIDE | SINOCHEM CORP (CN) | 2015-10-21 | — | — | EP | disclosed |
| US-20140256745-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256745-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| JP-H09100277-A | NEW TETRAZOLINONE DERIVATIVE AND HERBICIDE | NISSAN CHEM IND LTD | 1997-04-15 | — | — | JP | disclosed |
| EP-0405808-B1 | Phenoxyalkylamine derivatives and insecticides, acaricides and fungicides | UBE INDUSTRIES (JP) | 1995-01-11 | — | — | EP | disclosed |
| US-5366991-A | Agriculture | ENI CHEM SYNTHESIS S.P.A. (IT) | 1994-11-22 | — | — | US | disclosed |
| EP-0590720-A1 | Pyrazolecarboxamides exhibiting insecticidal and acaricidal activity | MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1994-04-06 | — | — | EP | disclosed |
| US-5264448-A | Thioamides, oxazole ring, insecticides, miticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5206259-A | Insecticides, acaricides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-04-27 | — | — | US | disclosed |
| US-5039692-A | Phenoxyalkylamine derivatives, and insecticides, acaricides and fungicides | UBE INDUSTRIES, LTD. (JP) | 1991-08-13 | — | — | US | disclosed |
| EP-0405808-A1 | Phenoxyalkylamine derivatives and insecticides, acaricides and fungicides | UBE INDUSTRIES, LTD. (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0394043-A1 | An amide compound and its production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556888-B2 | Pyrazole compounds or salts thereof, preparation methods therefor, herbicidal compositions and use thereof | WEE1, CYP4F11, SLC39A11 | KDM4E 3994/4885SMN1; SMN2 4764/4885LMNA 3596/4885 |
| US-20140256745-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | KDM4E 4057/4885SMN1; SMN2 854/4885LMNA 1306/4885 |
| US-20180105513-A1 | PYRAZOLE COMPOUNDS OR SALTS THEREOF, PREPARATION METHODS THEREFOR, HERBICIDAL COMPOSITIONS AND USE THEREOF | WEE1, CYP4F11, SLC39A11 | KDM4E 3994/4885SMN1; SMN2 4764/4885LMNA 3596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.