Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11801976 | 0.79 | KDM4E (0.46) | KDM4EHTTEPHX2ALOX5OPRK1 | |
| Hydrochloric Acid SCHEMBL27551926 | 0.77 | SMN1; SMN2 (0.49) | HTTMAPTSMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL11803547 | 0.72 | EPHX2 (0.43) | KDM4EHTTEPHX2ALOX5OPRK1 | |
| SCHEMBL15996424 | 0.70 | EPHX2 (0.38) | KDM4EHTTEPHX2ALOX5SMN1; SMN2 | |
| SCHEMBL6937606 | 0.68 | GRIN2D (0.43) | KDM4EHTTSMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL20841986 | 0.67 | GRIN2D (0.52) | EPHX2SMN1; SMN2ALDH1A1GRIN2DGRIN3B | |
| SCHEMBL11153629 | 0.66 | GRIN2D (0.44) | EPHX2MAPTALDH1A1GRIN2DGRIN3B | |
| SCHEMBL14341887 | 0.66 | KDM4E (0.56) | KDM4EHTTEPHX2ALOX5ALDH1A1 | |
| SCHEMBL17337978 | 0.66 | GRIN2D (0.39) | KDM4EHTTEPHX2ALOX5ALDH1A1 | |
| SCHEMBL11008002 | 0.66 | OPRK1 (0.47) | KDM4EOPRK1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741346-B2 | Angiogenesis inhibitor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-06-22 | — | — | US | disclosed |
| US-20080161270-A1 | Angiogenesis inhibitors | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2008-07-03 | — | — | US | disclosed |
| US-20050014800-A1 | Angiogenesis inhibitor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-01-20 | — | — | US | disclosed |
| EP-1457205-A1 | ANGIOGENESIS INHIBITOR | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161270-A1 | Angiogenesis inhibitors | FLT4, KDR, FLT1 | KDM4E 1375/4885HTT 4594/4885EPHX2 2354/4885 |
| US-20050014800-A1 | Angiogenesis inhibitor | FLT4, KDR, FLT1 | KDM4E 1368/4885HTT 4617/4885EPHX2 2296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.