Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 12/20 | 0.61 |
| ▸ | GAA | P10253 | 8/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | SNCA | P37840 | 2/20 | 0.61 |
| ▸ | CYBB | P04839 | 2/20 | 0.61 |
| ▸ | NOX3 | Q9HBY0 | 2/20 | 0.61 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586107 | 0.99 | NOX1 (0.62) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL13269666 | 0.79 | NOX1 (0.63) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL29375737 | 0.76 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL28073776 | 0.76 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL342449 | 0.76 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL3573034 | 0.76 | NOX1 (0.56) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL3573032 | 0.76 | NOX1 (0.56) | NOX1GAAMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3587396 | 0.75 | NOX1 (0.54) | NOX1GAAMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3587395 | 0.75 | NOX1 (0.54) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL3586011 | 0.74 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642591-B2 | Composition containing amidine derivatives or carboxamide derivatives and steroids, as a medicament | IPSEN PHARMA S.A.S. (FR) | 2014-02-04 | — | — | US | disclosed |
| US-7659266-B2 | Amidine derivatives and their applications as a medicament | S.C.R.A.S. (FR) | 2010-02-09 | — | — | US | disclosed |
| US-20090018120-A1 | AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018120-A1 | AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT | CAPN2, CAPN9, CAPN1 | ACHE 616/4885NOX1 196/4885GAA 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.