Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | PARP1 | P09874 | 18/20 | 0.67 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.66 |
| ▸ | DHODH | Q02127 | 2/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.61 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582368 | 0.96 | AURKB (0.64) | AURKBAURKAPARP1PARP2DHODH | |
| SCHEMBL3582857 | 0.89 | PARP1 (0.66) | AURKBPARP1PARP2DHODHPLK4 | |
| SCHEMBL3587286 | 0.88 | AURKA (0.76) | AURKBAURKAPARP1PARP2DHODH | |
| SCHEMBL3576975 | 0.85 | PARP1 (0.72) | AURKBAURKAPARP1PARP2DHODH | |
| SCHEMBL6805718 | 0.85 | AURKA (0.72) | AURKBAURKAPARP1PARP2DHODH | |
| SCHEMBL3582276 | 0.85 | AURKB (0.82) | AURKBAURKAPARP1PARP2DHODH | |
| SCHEMBL31413270 | 0.84 | PARP1 (0.82) | PARP1PARP2DHODH | |
| SCHEMBL3577220 | 0.84 | AURKA (0.71) | AURKBAURKAPARP1PARP2DHODH | |
| Hydrochloric Acid SCHEMBL31413181 | 0.84 | PARP1 (0.80) | PARP1PARP2DHODH | |
| SCHEMBL30811238 | 0.84 | PARP1 (0.84) | AURKBAURKAPARP1PARP2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |