Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 2/20 | 0.36 |
| ▸ | CCR9 | P51686 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 3/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576692 | 0.89 | ESRRG (0.37) | ESRRGCCR9C5AR1ESRRBCNR1 | |
| SCHEMBL3581193 | 0.87 | CCR9 (0.39) | CCR9C5AR1F10KLKB1 | |
| SCHEMBL3570653 | 0.85 | CNR1 (0.39) | C5AR1CNR1HDAC8HDAC6 | |
| SCHEMBL3582723 | 0.84 | HCRTR1 (0.37) | ESRRGCCR9HCRTR1HCRTR2F10 | |
| SCHEMBL3576379 | 0.84 | HSP90AA1 (0.46) | CCR9HSP90AA1HDAC3HDAC8HDAC6 | |
| SCHEMBL3577915 | 0.81 | F10 (0.38) | ESRRGCCR9CNR1F10TP53 | |
| SCHEMBL3580374 | 0.81 | ESRRG (0.36) | ESRRGCCR9ESRRBHSP90AA1TP53 | |
| SCHEMBL3569329 | 0.81 | C5AR1 (0.41) | C5AR1CNR1F10KLKB1 | |
| SCHEMBL1397638 | 0.81 | HCRTR1 (0.37) | CCR9HCRTR1HCRTR2 | |
| SCHEMBL3587153 | 0.80 | ESRRG (0.36) | ESRRGHCRTR1HCRTR2C5AR1ESRRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |