Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581366 | 0.88 | HCRTR1 (0.38) | HCRTR1HCRTR2TRPM8RAF1MAP2K1 | |
| SCHEMBL3570653 | 0.87 | CNR1 (0.39) | TRPM8CETP | |
| SCHEMBL3584236 | 0.85 | HCRTR1 (0.42) | HCRTR1HCRTR2PTGER2 | |
| SCHEMBL3581175 | 0.84 | ESRRG (0.36) | HCRTR1HCRTR2CCR9KLKB1TP53 | |
| SCHEMBL3576692 | 0.83 | ESRRG (0.37) | TRPM8CCR9ESRRGF10 | |
| SCHEMBL3576379 | 0.81 | HSP90AA1 (0.46) | CCR9 | |
| SCHEMBL3581186 | 0.81 | CNR1 (0.39) | — | |
| SCHEMBL1397590 | 0.80 | HCRTR1 (0.40) | HCRTR1HCRTR2CETPMAPT | |
| SCHEMBL3583456 | 0.80 | CNR1 (0.38) | — | |
| SCHEMBL3569329 | 0.80 | C5AR1 (0.41) | KLKB1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |