Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | TEK | Q02763 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 7/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27672591 | 0.91 | LCK (0.42) | LCKTEKKDRGRM5FFAR1 | |
| SCHEMBL3568737 | 0.87 | GRM5 (0.37) | LCKTEKKDRGRM5NPSR1 | |
| SCHEMBL3581653 | 0.84 | ADK (0.38) | KDRGRM5FFAR1ASIC3NPSR1 | |
| SCHEMBL4716259 | 0.84 | LCK (0.43) | LCKTEKKDRGRM5FFAR1 | |
| SCHEMBL27672603 | 0.81 | LCK (0.42) | LCKTEKKDRGRM5 | |
| SCHEMBL27672622 | 0.81 | VNN1 (0.42) | LCKTEKKDRGRM5FFAR1 | |
| SCHEMBL27672607 | 0.80 | GRM5 (0.45) | LCKTEKKDRGRM5 | |
| SCHEMBL27672587 | 0.80 | GRM5 (0.47) | LCKTEKKDRGRM5 | |
| SCHEMBL27652405 | 0.79 | LCK (0.41) | LCKTEKKDRGRM5 | |
| SCHEMBL27652400 | 0.78 | TEK (0.52) | LCKTEKKDRGRM5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | TEK, TYMP, TIE1 | LCK 326/4885TEK 1/4885KDR 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.