Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13066493 | 0.80 | ALDH1A1 (1.00) | ALDH1A1GAALMNAPTGDR2APAF1 | |
| SCHEMBL26927006 | 0.79 | ALDH1A1 (0.50) | ALDH1A1GAALMNAPTGDR2MAPT | |
| SCHEMBL111808 | 0.77 | ALDH1A1 (0.67) | ALDH1A1GAALMNAPTGDR2P2RX7 | |
| SCHEMBL3585241 | 0.77 | ALDH1A1 (0.67) | ALDH1A1GAALMNAAPAF1 | |
| SCHEMBL13682946 | 0.77 | ALDH1A1 (0.67) | ALDH1A1GAALMNAPTGDR2APAF1 | |
| SCHEMBL19007302 | 0.76 | ALDH1A1 (0.65) | ALDH1A1GAALMNAPTGDR2APAF1 | |
| SCHEMBL26037894 | 0.76 | ALDH1A1 (0.65) | ALDH1A1GAALMNAPTGDR2APAF1 | |
| Ethane SCHEMBL11828584 | 0.76 | ALDH1A1 (0.65) | ALDH1A1GAALMNAAPAF1 | |
| SCHEMBL29953641 | 0.76 | ALDH1A1 (0.65) | ALDH1A1GAALMNAPTGDR2APAF1 | |
| SCHEMBL8659165 | 0.75 | ALDH1A1 (0.35) | ALDH1A1GAAAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | ALDH1A1 971/4885GAA 4433/4885LMNA 4877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.