Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9736423 | 0.98 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL9736415 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL31187398 | 0.87 | MEN1 (0.54) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL358977 | 0.87 | MEN1 (0.54) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL22149604 | 0.86 | KDM4E (0.78) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL978583 | 0.85 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL8204839 | 0.83 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL5695675 | 0.83 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL28552806 | 0.83 | KMT2A (0.54) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL617928 | 0.82 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118894823-A | Naphthylamide compound serving as VEGFR inhibitor and application thereof | 重庆医科大学 | 2024-11-05 | — | — | CN | disclosed |
| CN-108329232-B | Hydrazide derivative and application thereof | 浙江大学 | 2021-04-16 | — | — | CN | disclosed |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | HOFFMANN-LA ROCHE INC. | 2018-10-18 | — | — | US | disclosed |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-2593457-B1 | PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2017-08-23 | — | — | EP | disclosed |
| EP-2593457-B1 | PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2017-08-23 | — | — | EP | disclosed |
| US-20160207936-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN-LA ROCHE INC. | 2016-07-21 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| US-6211385-B1 | STARTING FROM THIOCHROMAN-4-ONE COMPOUND | ALLERGAN SALES, INC. | 2001-04-03 | — | — | US | disclosed |
| WO-2000068220-A1 | PROCESS FOR PREPARING SUBSTITUTED BENZO[1,2-G]-CHROM-3-ENE, BENZO[1,2-G]-THIOCHROM-3-ENE AND BENZO[1,2-G]-1,2-DIHYDROQUINOLINE DERIVATIVES | ALLERGAN SALES, INC. (US) | 2000-11-16 | — | — | WO | disclosed |
| US-6043381-A | Process for preparing substituted benzo[1,2-g]-chrom-3-ene, benzo[1,2-g]-thiochrom-3-ene and benzo[1,2-g]-1,2-dihydroquinoline derivatives | ALLERGAN SALES, INC. (US) | 2000-03-28 | — | — | US | disclosed |
| US-5426189-A | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-06-20 | — | — | US | disclosed |
| US-5334728-A | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1994-08-02 | — | — | US | disclosed |
| US-5186921-A | 3-methoxy-n(1-ethyl-2-pyrrolidinyl)methyl)naphthyl-2-carboxy amide compounds for imaging human brains; good retention stability | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1993-02-16 | — | — | US | disclosed |
| US-5122361-A | 2-Pyrrolidinylmethylcarboxamido-2,3-dihydrobenzofuran type compounds | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0393838-A1 | Dopamine receptor ligands and imaging agents | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1990-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207936-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885ALDH1A1 2519/4885HPGD 3857/4885 |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885ALDH1A1 2519/4885HPGD 3857/4885 |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885ALDH1A1 2519/4885HPGD 3857/4885 |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | IRAK4, IRAK1, IRAK2 | KDM4E 261/4885ALDH1A1 2519/4885HPGD 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.