Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.74 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.74 |
| ▸ | TOP1 | P11387 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320925 | 0.85 | ADORA2A (0.74) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL14391096 | 0.81 | ADORA2A (0.61) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL5593424 | 0.80 | ADORA1 (0.66) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL3591730 | 0.80 | ADORA2A (0.52) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL13545962 | 0.78 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL13545961 | 0.76 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL13545954 | 0.75 | ADORA2A (0.59) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL13545958 | 0.74 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BTOP1PIM1 | |
| SCHEMBL16295046 | 0.74 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BTOP1ALDH1A1 | |
| SCHEMBL3587811 | 0.74 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BTOP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
| EP-2019827-A1 | INTEGRASE INHIBITORS 3 | Avexa Limited (AU) | 2009-02-04 | — | — | EP | disclosed |
| WO-2007124546-A1 | INTEGRASE INHIBITORS 3 | AVEXA LIMITED (AU) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007124545-A1 | INTEGRASE INHIBITORS - 2 | AVEXA LIMITED (AU) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | TYMP, IMPDH1, IMPDH2 | ADORA2A 3605/4885ADORA1 2470/4885ADORA2B 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.