Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | PARP1 | P09874 | 16/20 | 0.62 |
| ▸ | DHODH | Q02127 | 3/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576975 | 0.87 | PARP1 (0.72) | AURKBAURKAPARP1DHODHPARP2 | |
| SCHEMBL6581301 | 0.86 | AURKB (0.47) | AURKBAURKAPARP1DHODHCHEK2 | |
| SCHEMBL3582303 | 0.84 | CHEK2 (0.51) | AURKBAURKAPARP1DHODHCHEK2 | |
| SCHEMBL3579915 | 0.83 | PARP1 (0.67) | AURKBAURKAPARP1DHODHPARP2 | |
| SCHEMBL3587286 | 0.83 | AURKA (0.76) | AURKBAURKAPARP1DHODHPARP2 | |
| SCHEMBL7762879 | 0.83 | GAA (0.51) | AURKBAURKA | |
| SCHEMBL3580117 | 0.82 | AURKB (0.77) | AURKBAURKAPARP1DHODHCHEK2 | |
| SCHEMBL3580352 | 0.82 | AURKB (0.68) | AURKBAURKAPARP1DHODHCHEK2 | |
| SCHEMBL3582276 | 0.81 | AURKB (0.82) | AURKBAURKAPARP1DHODHPARP2 | |
| SCHEMBL3577220 | 0.80 | AURKA (0.71) | AURKBAURKAPARP1DHODHPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |