Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 11/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DHPS | P49366 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896689 | 0.73 | PARP1 (0.71) | PARP1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL1590571 | 0.73 | NPC1 (0.41) | PARP1ALDH1A1SMN1; SMN2USP7CYP3A4 | |
| SCHEMBL1591499 | 0.73 | KMT2A (0.48) | KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9394351 | 0.72 | PARP1 (0.61) | PARP1KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1591352 | 0.72 | KCNQ2 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1591761 | 0.72 | KMT2A (0.47) | KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL1589954 | 0.72 | P2RX7 (0.45) | KDM4EALDH1A1SMN1; SMN2CYP3A4HPGD | |
| SCHEMBL1590832 | 0.72 | USP7 (0.45) | USP7 | |
| SCHEMBL1590597 | 0.72 | POLB (0.42) | KDM4EALDH1A1HPGD | |
| SCHEMBL13243908 | 0.72 | ALDH1A1 (0.41) | KDM4EALDH1A1TSHRHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816371-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2010-10-19 | — | — | US | claimed |