Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583941 | 0.94 | ALDH1A1 (0.68) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL3572982 | 0.84 | ALDH1A1 (0.67) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL3580260 | 0.81 | ALDH1A1 (1.00) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL8141732 | 0.79 | ALDH1A1 (0.63) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL22451332 | 0.78 | KDM4E (0.67) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL13440423 | 0.78 | ALDH1A1 (0.67) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL522242 | 0.75 | ALDH1A1 (0.57) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL14672079 | 0.73 | ALDH1A1 (0.67) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL10204428 | 0.72 | ALDH1A1 (0.71) | ALDH1A1GAAKDM4EHTTNPSR1 | |
| SCHEMBL12553258 | 0.71 | NR4A2 (0.51) | ALDH1A1GAAKDM4EHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |
| US-20060252785-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252785-A1 | Heterocyclic antiviral compounds | EIF2AK2, HAVCR2, POLR2E | ALDH1A1 431/4885GAA 925/4885KDM4E 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.