Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582819 | 0.93 | LMNA (0.38) | LMNANLRP3C5AR1MCHR1F2 | |
| SCHEMBL3586383 | 0.90 | NLRP3 (0.39) | LMNANLRP3C5AR1MCHR1F2 | |
| SCHEMBL3579684 | 0.85 | CNR1 (0.40) | LMNAC5AR1LPAR1LPAR5SLC2A1 | |
| SCHEMBL3571491 | 0.85 | C5AR1 (0.42) | LMNAC5AR1F10GAALPAR1 | |
| SCHEMBL3586617 | 0.83 | C5AR1 (0.41) | LMNANLRP3C5AR1F10GAA | |
| SCHEMBL3576622 | 0.83 | LMNA (0.37) | LMNAC5AR1LPAR1MAPTNPSR1 | |
| SCHEMBL3571528 | 0.83 | TP53 (0.41) | LMNAC5AR1F10GAALPAR1 | |
| SCHEMBL9958528 | 0.81 | F2 (0.39) | LMNANLRP3C5AR1MCHR1F2 | |
| SCHEMBL3575259 | 0.81 | LMNA (0.41) | LMNAC5AR1GAASMN1; SMN2SLC2A1 | |
| SCHEMBL3571486 | 0.80 | LMNA (0.41) | LMNAC5AR1GAASMN1; SMN2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |