Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
| ▸ | ADH5 | P11766 | 2/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.41 |
| ▸ | CD38 | P28907 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575391 | 0.88 | DHODH (0.47) | DHODHGRK6ADH5FBP1NPC1 | |
| SCHEMBL3585590 | 0.83 | PKN1 (0.54) | DHODHROCK1 | |
| SCHEMBL3577856 | 0.83 | KDM4E (0.50) | DHODHGRK6ADH5FBP1NPC1 | |
| SCHEMBL6805689 | 0.82 | PKN1 (0.49) | ALOX15CYP3A4CYP2D6ROCK1 | |
| SCHEMBL3581194 | 0.77 | AURKA (0.49) | KMT2AMEN1 | |
| SCHEMBL3575386 | 0.73 | PARP1 (0.67) | DHODHALOX15ROCK1 | |
| SCHEMBL3582143 | 0.71 | AURKB (0.56) | DHODH | |
| SCHEMBL3580322 | 0.71 | CHEK1 (0.61) | — | |
| SCHEMBL6582804 | 0.71 | HPSE (0.47) | DHODHGRK6ADH5NPC1RAB9A | |
| SCHEMBL6810489 | 0.70 | POLB (0.49) | NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |