Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 6/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13282465 | 0.94 | HRH3 (0.47) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3586599 | 0.93 | PRKAA2 (0.38) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16327050 | 0.92 | PRKAA2 (0.40) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL16327013 | 0.88 | HRH3 (0.44) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3596047 | 0.88 | SIGMAR1 (0.40) | PRKAA2HRH3MAOAMAOBCHRM4 | |
| SCHEMBL3588625 | 0.88 | HRH2 (0.37) | GPBAR1 | |
| SCHEMBL3589821 | 0.87 | PRKAA2 (0.37) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL13254377 | 0.87 | KCNH2 (0.36) | PRKAA2HRH1CCR3KCNH2 | |
| SCHEMBL3593937 | 0.87 | KDM1A (0.37) | PRKAA2GPBAR1MAOAMAOB | |
| SCHEMBL3587512 | 0.87 | GPR6 (0.36) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190768-A1 | NOVEL FUSED PYROLE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-07-29 | — | — | US | disclosed |
| US-20100190768-A1 | NOVEL FUSED PYROLE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-07-29 | — | — | US | disclosed |
| EP-1930320-A1 | NOVEL FUSED PYRROLE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-06-11 | — | — | EP | disclosed |
| EP-1930320-A1 | NOVEL FUSED PYRROLE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190768-A1 | NOVEL FUSED PYROLE DERIVATIVE | NR3C1, NR3C2, NR0B1 | PRKAA2 2729/4885PRKAB2 3133/4885PRKAG1 3104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.