Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCND2 | P30279 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1356046 | 0.86 | FLT3 (0.54) | FLT3AURKACDK1CCNB1EIF2AK4 | |
| SCHEMBL1355988 | 0.84 | FLT3 (0.64) | FLT3AURKACDK1CCNB1EIF2AK4 | |
| SCHEMBL3585855 | 0.80 | CDK4 (0.59) | AURKACDK1CCNB1CDK4CCND1 | |
| SCHEMBL1355974 | 0.80 | DCLK1 (0.46) | FLT3AURKACDK1CCNB1DCLK1 | |
| SCHEMBL1662621 | 0.80 | EIF2AK4 (0.52) | FLT3AURKACDK1CCNB1EIF2AK4 | |
| SCHEMBL1353795 | 0.78 | DCLK1 (0.52) | FLT3AURKACDK1CCNB1DCLK1 | |
| SCHEMBL1356282 | 0.76 | FLT3 (0.52) | FLT3AURKACDK1CCNB1DCLK1 | |
| SCHEMBL1355910 | 0.74 | FGFR4 (0.50) | FLT3AURKACDK1CCNB1EIF2AK4 | |
| SCHEMBL1355845 | 0.74 | EIF2AK4 (0.60) | FLT3AURKAEIF2AK4PTK2ALDH1A1 | |
| SCHEMBL31299824 | 0.74 | PDGFRB (0.45) | AURKACDK1CCNB1EIF2AK4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
| EP-2108019-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094575-A2 | 1-H-PYRAZOLO(3,4B)PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | FLT3 718/4885AURKA 10/4885CDK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.