Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.59 |
| ▸ | CCND3 | P30281 | 8/20 | 0.59 |
| ▸ | CCND1 | P24385 | 7/20 | 0.59 |
| ▸ | CCND2 | P30279 | 7/20 | 0.59 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 4/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344015 | 0.89 | CDK4 (0.66) | CDK4CCND3CCND1CCND2MAP4K1 | |
| SCHEMBL1355798 | 0.87 | CDK4 (0.73) | CDK4CCND3CCND1CCND2EGFR | |
| SCHEMBL1353760 | 0.84 | EGFR (0.65) | CDK4CCND3CCND1CCND2EGFR | |
| SCHEMBL3571516 | 0.84 | EGFR (0.56) | CDK4CCND3CCND1CCND2MAP4K1 | |
| SCHEMBL1355286 | 0.81 | CDK4 (0.59) | CDK4CCND3CCND1CCND2MAP4K1 | |
| SCHEMBL3586476 | 0.80 | FLT3 (0.48) | CDK4CCND3CCND1CCND2AURKA | |
| SCHEMBL18001919 | 0.79 | JAK3 (0.73) | EGFRFGFR1SRC | |
| SCHEMBL1355810 | 0.79 | CDK4 (0.60) | CDK4CCND3CCND1CCND2EGFR | |
| SCHEMBL1355147 | 0.79 | TBK1 (0.61) | CDK4CCND3EGFRAURKAFGFR4 | |
| SCHEMBL27174693 | 0.78 | MAP4K1 (0.73) | CDK4CCND3CCND1CCND2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | CDK4 102/4885CCND3 256/4885CCND1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.