Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368905 | 0.96 | PARP1 (0.49) | PARP1GPR119NR3C1 | |
| SCHEMBL358653 | 0.94 | PARP1 (0.47) | PARP1GPR119NR3C1 | |
| SCHEMBL360298 | 0.91 | PARP1 (0.47) | PARP1 | |
| SCHEMBL358681 | 0.90 | EED (0.46) | PARP1GPR119NR3C1PRKCGPRKCB | |
| SCHEMBL359239 | 0.89 | PARP1 (0.51) | PARP1GPR119NR3C1 | |
| SCHEMBL359678 | 0.89 | PARP1 (0.47) | PARP1 | |
| SCHEMBL359223 | 0.87 | PARP1 (0.49) | PARP1GPR119 | |
| SCHEMBL10173016 | 0.85 | PARP1 (0.51) | PARP1 | |
| SCHEMBL359388 | 0.83 | PARP1 (0.50) | PARP1 | |
| SCHEMBL370739 | 0.82 | PARP1 (0.46) | PARP1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |