Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.40 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359451 | 0.94 | PARP1 (0.51) | PARP1BTKJAK2JAK1PIK3CD | |
| SCHEMBL359239 | 0.94 | PARP1 (0.51) | PARP1 | |
| SCHEMBL358920 | 0.83 | NR3C1 (0.43) | PARP1 | |
| SCHEMBL358670 | 0.83 | PARP1 (0.52) | PARP1 | |
| SCHEMBL360298 | 0.81 | PARP1 (0.47) | PARP1JAK2JAK1 | |
| SCHEMBL359223 | 0.81 | PARP1 (0.49) | PARP1BTKJAK2JAK1SRC | |
| SCHEMBL357915 | 0.81 | PARP1 (0.43) | PARP1 | |
| SCHEMBL361173 | 0.80 | PARP1 (0.41) | PARP1 | |
| SCHEMBL368905 | 0.80 | PARP1 (0.49) | PARP1 | |
| SCHEMBL359678 | 0.79 | PARP1 (0.47) | PARP1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |