Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368905 | 0.90 | PARP1 (0.49) | PARP1 | |
| SCHEMBL358333 | 0.85 | PARP1 (0.48) | PARP1PARP2MAP3K7TAB1AURKA | |
| SCHEMBL358670 | 0.85 | PARP1 (0.52) | PARP1 | |
| SCHEMBL359581 | 0.83 | RPS6KB1 (0.48) | PARP1PARP2AURKARPS6KB1 | |
| SCHEMBL358653 | 0.80 | PARP1 (0.47) | PARP1 | |
| SCHEMBL358621 | 0.79 | RPS6KB1 (0.47) | PARP1PARP2PARP14AURKARPS6KB1 | |
| SCHEMBL360298 | 0.79 | PARP1 (0.47) | PARP1JAK2 | |
| SCHEMBL27917361 | 0.79 | IGF1R (0.38) | PARP1KMT2APARP14 | |
| SCHEMBL358735 | 0.77 | PARP1 (0.49) | PARP1PARP2PARP14AURKARPS6KB1 | |
| SCHEMBL359678 | 0.77 | PARP1 (0.47) | PARP1JAK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |