Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.47 |
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.42 |
| ▸ | GRM6 | O15303 | 6/20 | 0.42 |
| ▸ | GRM8 | O00222 | 3/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 2/20 | 0.38 |
| ▸ | ARG2 | P78540 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25907203 | 0.77 | GRM2 (0.42) | GRM2GRM5GRM1GRM4GRM6 | |
| SCHEMBL12800122 | 0.77 | GRM2 (0.42) | GRM2GRM5GRM1GRM4GRM6 | |
| SCHEMBL15428478 | 0.70 | — | — | |
| SCHEMBL15909554 | 0.70 | — | — | |
| SCHEMBL11387548 | 0.70 | APLNR (0.31) | GRM2GRM5GRM1ARG1ARG2 | |
| SCHEMBL15404487 | 0.69 | GRM2 (0.39) | GRM2GRM5GRM1GRM6GRM3 | |
| Hydrochloric Acid SCHEMBL25384535 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL9277699 | 0.69 | — | — | |
| SCHEMBL16240415 | 0.68 | — | — | |
| SCHEMBL3294258 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063065-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | INPHARMATICA LIMITED (GB) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063065-A1 | THIOPHENE DERIVATIVES AS PPAR AGONISTS I | PPARG, PPARD, PPARA | GRM2 656/4885GRM5 783/4885GRM1 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.