Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8243047 | 0.88 | KMT2A (0.41) | KMT2APOLBABL1RIN1TDP1 | |
| SCHEMBL22273295 | 0.84 | BRD4 (0.40) | KMT2AMGAMGAASIMGAM2 | |
| SCHEMBL22264486 | 0.84 | BRD4 (0.40) | KMT2AMGAMGAASIMGAM2 | |
| SCHEMBL8277704 | 0.83 | KMT2A (0.40) | KMT2APOLBABL1RIN1TDP1 | |
| SCHEMBL27684837 | 0.81 | KMT2A (0.38) | KMT2APOLBABL1RIN1TDP1 | |
| SCHEMBL3587342 | 0.79 | TP53 (0.51) | KMT2ATP53L3MBTL1ALDH1A1TSHR | |
| SCHEMBL3967641 | 0.79 | TLR4 (0.46) | KMT2APOLBABL1RIN1TDP1 | |
| SCHEMBL8276670 | 0.78 | KMT2A (0.37) | KMT2APOLBABL1RIN1TDP1 | |
| SCHEMBL9442546 | 0.77 | KMT2A (0.36) | KMT2APOLBABL1RIN1TDP1 | |
| SCHEMBL3969772 | 0.76 | L3MBTL1 (0.44) | KMT2ACYP2D6TP53L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8203004-B2 | Tetrahydroindole derivatives for treatment of alzheimer's disease | MERCK, SHARP & DOHME LIMITED (GB) | 2012-06-19 | — | — | US | disclosed |
| US-20100016308-A1 | Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016308-A1 | Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease | BACE1, BACE2, PSEN2 | KMT2A 3305/4885POLB 1817/4885ABL1 3904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.