Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 19/20 | 0.66 |
| ▸ | GSK3B | P49841 | 19/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | PAK4 | O96013 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | FYN | P06241 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | CDK8 | P49336 | 2/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.66 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.66 |
| ▸ | LTK | P29376 | 1/20 | 0.66 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.66 |
| ▸ | CDK7 | P50613 | 1/20 | 0.66 |
| ▸ | CDK9 | P50750 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13502526 | 0.80 | GSK3A (1.00) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL3580619 | 0.79 | GSK3A (0.63) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL12205754 | 0.78 | GSK3A (0.82) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL379047 | 0.77 | GSK3A (1.00) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL27824303 | 0.70 | GSK3A (0.55) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL13926127 | 0.69 | GSK3A (0.80) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL27824304 | 0.69 | GSK3A (0.72) | GSK3AGSK3BCDK5MAPK8AURKA | |
| Bromide SCHEMBL490395 | 0.69 | GSK3A (0.97) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL27761166 | 0.69 | GSK3A (0.62) | GSK3AGSK3BCDK5MAPK8AURKA | |
| SCHEMBL3100624 | 0.68 | GSK3A (0.70) | GSK3AGSK3BCDK5MAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140142110-A1 | KINASE INHIBITOR | SANOFI (FR) | 2014-05-22 | — | — | US | disclosed |
| US-8658649-B2 | Kinase inhibitor | SANOFI (FR) | 2014-02-25 | — | — | US | disclosed |
| EP-2094708-B1 | A PYRROLOPYRAZIN AS SYK-KINASE INHIBITOR | SANOFI SA (FR) | 2013-10-23 | — | — | EP | disclosed |
| US-20100035884-A1 | KINASE INHIBITOR | SANOFI-AVENTIS (FR) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035884-A1 | KINASE INHIBITOR | MAP3K1, MAP3K20, MAP3K19 | GSK3A 276/4885GSK3B 266/4885CDK5 145/4885 |
| US-20140142110-A1 | KINASE INHIBITOR | MAP3K1, MAP3K20, MAP3K19 | GSK3A 276/4885GSK3B 266/4885CDK5 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.