Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2535856 | 0.82 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL966501 | 0.80 | NPSR1 (0.46) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL122021 | 0.79 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL1490972 | 0.78 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL358839 | 0.78 | HPGD (0.43) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL23017397 | 0.78 | RAB9A (0.63) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL964220 | 0.78 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL363979 | 0.76 | HPGD (0.41) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL28184225 | 0.76 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL7918203 | 0.75 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009646-A1 | METHODS OF TREATING FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS | XENOPORT, INC. (US) | 2012-01-19 | — | — | WO | disclosed |