Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP9 | P55211 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358839 | 0.85 | HPGD (0.43) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL2358907 | 0.79 | SMN1; SMN2 (0.62) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL351929 | 0.77 | CASP3 (0.42) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL349358 | 0.77 | CASP3 (0.42) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL358841 | 0.76 | NPC1 (0.48) | HPGDSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL349357 | 0.75 | CRHBP (0.45) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL351928 | 0.75 | CRHBP (0.45) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL1196294 | 0.71 | SMN1; SMN2 (0.61) | HPGDSMN1; SMN2RAB9ANPC1CYP1A2 | |
| SCHEMBL17928315 | 0.71 | TSHR (0.35) | SMN1; SMN2ALOX15 | |
| SCHEMBL12132613 | 0.70 | CHRNB2 (0.39) | SMN1; SMN2CYP2D6ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009646-A1 | METHODS OF TREATING FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS | XENOPORT, INC. (US) | 2012-01-19 | — | — | WO | disclosed |