Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11315591 | 0.89 | TDP1 (0.42) | TSHRTDP1MAPTCYP1A2LMNA | |
| SCHEMBL11245975 | 0.87 | IDO1 (0.56) | IDO1TDP1MAPTCYP1A2LMNA | |
| SCHEMBL2311706 | 0.84 | TDP1 (0.39) | TSHRTDP1CYP1A2CDK2ALDH1A1 | |
| SCHEMBL2987022 | 0.84 | LMNA (0.53) | IDO1TSHRHPGDHSD17B10TDP1 | |
| SCHEMBL2313375 | 0.84 | TDP1 (0.39) | TSHRTDP1CYP1A2CDK2ALDH1A1 | |
| SCHEMBL5545182 | 0.81 | IAPP (0.47) | IDO1TSHRHPGDHSD17B10TDP1 | |
| SCHEMBL12235264 | 0.79 | TDP1 (0.48) | IDO1TSHRHPGDHSD17B10TDP1 | |
| SCHEMBL5540925 | 0.78 | BID (0.50) | HSD17B10MAPTALOX15KDM4EIAPP | |
| SCHEMBL30046415 | 0.77 | IAPP (0.57) | TSHRHPGDHSD17B10TDP1MAPT | |
| SCHEMBL1951548 | 0.77 | IAPP (0.57) | TSHRHPGDHSD17B10TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2495245-A2 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | FOB Synthesis, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2495245-A2 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | FOB Synthesis, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | CHOI WOO-BAEG | 2010-03-25 | — | — | US | disclosed |
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | CHOI WOO-BAEG | 2010-03-25 | — | — | US | disclosed |
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | CHOI WOO-BAEG | 2010-03-25 | — | — | US | disclosed |
| US-7632828-B2 | Gram-positive carbapenem antibacterials and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632828-B2 | Gram-positive carbapenem antibacterials and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632828-B2 | Gram-positive carbapenem antibacterials and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2009-12-15 | — | — | US | disclosed |
| EP-1765821-A4 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | FOB SYNTHESIS INC (US) | 2009-05-20 | — | — | EP | disclosed |
| EP-1765821-A2 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | FOB Synthesis, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060074070-A1 | Gram-positive carbapenem antibacterials and processes for their preparation | FOB SYNTHESIS, INC. | 2006-04-06 | — | — | US | disclosed |
| WO-2005123069-A2 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | FOB SYNTHESIS, INC. (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074070-A1 | Gram-positive carbapenem antibacterials and processes for their preparation | MGAM, GSK3B, GSK3A | IDO1 1133/4885TSHR 4841/4885HPGD 1367/4885 |
| US-20100075945-A1 | GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION | MGAM, GSK3B, GSK3A | IDO1 1133/4885TSHR 4841/4885HPGD 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.