Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20967569 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDM4EPLA2G10PLA2G5GSK3A | |
| SCHEMBL3591122 | 0.76 | APEX1 (0.44) | ALDH1A1KDM4EGAAL3MBTL1POLB | |
| SCHEMBL3582007 | 0.76 | ALDH1A1 (0.39) | ALDH1A1KDM4EPLA2G10PLA2G5GSK3A | |
| SCHEMBL18171779 | 0.71 | ALDH1A1 (0.64) | ALDH1A1KDM4EKMT2AGAATSHR | |
| SCHEMBL3593243 | 0.71 | HDAC6 (0.40) | ALDH1A1KDM4EPLA2G10PLA2G5KMT2A | |
| SCHEMBL3587945 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2ACACNA1BJAK2 | |
| SCHEMBL3571941 | 0.70 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AGAATSHR | |
| SCHEMBL4417899 | 0.70 | KDM4E (0.44) | ALDH1A1KDM4EPLA2G10PLA2G5KMT2A | |
| SCHEMBL24774078 | 0.69 | ALDH1A1 (0.41) | ALDH1A1KDM4EPLA2G10PLA2G5GSK3A | |
| SCHEMBL8177614 | 0.69 | KDM4E (0.43) | ALDH1A1KDM4EPLA2G10PLA2G5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | ALDH1A1 971/4885KDM4E 3447/4885PLA2G10 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.