Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10525275 | 0.82 | DRD2 (0.51) | DRD2DRD3TAAR1PTGS1PTGS2 | |
| SCHEMBL2030841 | 0.80 | TAAR1 (0.71) | TAAR1PTGS1PTGS2ADRA2AADRA2B | |
| SCHEMBL8671494 | 0.80 | TAAR1 (0.71) | DRD2DRD3TAAR1NPC1HDAC6 | |
| SCHEMBL721007 | 0.77 | TAAR1 (0.56) | TAAR1PTGS1PTGS2ADRA2AADRA2B | |
| SCHEMBL28985382 | 0.75 | TAAR1 (0.54) | TAAR1PTGS1PTGS2ADRA2AADRA2B | |
| SCHEMBL4059254 | 0.74 | TAAR1 (0.58) | DRD2DRD3TAAR1SMN1; SMN2 | |
| SCHEMBL2886837 | 0.73 | TAAR1 (0.52) | TAAR1PTGS1PTGS2ADRA2AADRA2B | |
| SCHEMBL7878372 | 0.73 | DRD2 (0.48) | DRD2DRD3TAAR1HCAR3ADRA2A | |
| SCHEMBL28449371 | 0.72 | TAAR1 (0.50) | TAAR1PTGS1PTGS2ADRA2AADRA2B | |
| SCHEMBL7705346 | 0.72 | MEN1 (0.51) | TAAR1PTGS1PTGS2TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237917-A2 | 1,1-Disubstituted cyclopropane derivatives, processes for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-23 | — | — | EP | claimed |
| US-20100010020-A1 | PHOSPHODIESTERASE 4 INHIBITORS | LIU RUIPING | 2010-01-14 | — | — | US | disclosed |
| EP-0237917-A2 | 1,1-Disubstituted cyclopropane derivatives, processes for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010020-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE3B, PDE3A | DRD2 2997/4885DRD3 2788/4885TAAR1 1215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.