Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589897 | 1.00 | P2RX7 (0.55) | P2RX7TP53MAPTTHRBPOLB | |
| SCHEMBL1591265 | 0.91 | P2RX7 (0.55) | P2RX7POLBSMN1; SMN2 | |
| SCHEMBL1591268 | 0.91 | P2RX7 (0.55) | P2RX7POLBSMN1; SMN2 | |
| SCHEMBL13135680 | 0.91 | P2RX7 (0.55) | P2RX7TP53MAPTSMN1; SMN2 | |
| SCHEMBL1591103 | 0.91 | P2RX7 (0.51) | P2RX7TP53MAPTTHRBPOLB | |
| SCHEMBL1591098 | 0.91 | P2RX7 (0.51) | P2RX7TP53MAPTTHRBPOLB | |
| SCHEMBL1591327 | 0.90 | P2RX7 (0.58) | P2RX7POLQALDH1A1 | |
| SCHEMBL1590469 | 0.90 | P2RX7 (0.58) | P2RX7POLQALDH1A1 | |
| SCHEMBL1590472 | 0.90 | P2RX7 (0.58) | P2RX7POLQALDH1A1 | |
| SCHEMBL14414491 | 0.89 | P2RX7 (0.59) | P2RX7TP53MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816371-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2010-10-19 | — | — | US | claimed |
| US-20070225324-A1 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | SECOND GENOME, INC. | 2007-09-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225324-A1 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | P2RX7, P2RX3, P2RX2 | P2RX7 1/4885TP53 4589/4885MAPT 4477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.