Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167690 | 1.00 | PSMB8 (0.42) | PSMB8PSMB5PSMB10PSMB2PSMB9 | |
| SCHEMBL3601473 | 0.89 | TP53 (0.38) | ALDH1A1POLBCAPN1ITGB1ITGA4 | |
| SCHEMBL13167689 | 0.86 | GAA (0.39) | ALDH1A1POLBL3MBTL1CAPN1ITGB1 | |
| SCHEMBL3594344 | 0.86 | NPC1 (0.42) | ALDH1A1KMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL3594340 | 0.86 | NPC1 (0.42) | ALDH1A1KMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL13167688 | 0.85 | TP53 (0.39) | ALDH1A1POLBKMT2AMEN1L3MBTL1 | |
| SCHEMBL13167677 | 0.84 | NPC1 (0.41) | ALDH1A1KMT2AMEN1L3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL2913793 | 0.84 | NPC1 (0.40) | ALDH1A1KMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL3595909 | 0.84 | KMT2A (0.42) | ALDH1A1KMT2AMEN1L3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL3584967 | 0.83 | KMT2A (0.41) | ALDH1A1KMT2AMEN1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | ZHANG HESHENG | 2010-09-23 | — | — | US | claimed |
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | ZHANG HESHENG | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | CCNH, CBR1, CBR3 | PSMB8 954/4885PSMB5 1526/4885PSMB10 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.