Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167688 | 0.89 | TP53 (0.39) | TP53CAPN1GAATACR1CYP3A4 | |
| SCHEMBL13167689 | 0.89 | GAA (0.39) | TP53CAPN1GAADDB1CRBN | |
| SCHEMBL13167690 | 0.89 | PSMB8 (0.42) | TP53CAPN1GAAMAP1LC3BITGB1 | |
| SCHEMBL3590346 | 0.89 | PSMB8 (0.42) | TP53CAPN1GAAMAP1LC3BITGB1 | |
| SCHEMBL3594808 | 0.85 | CYP3A4 (0.36) | DDB1CRBNMAP1LC3BCYP3A4CYP2D6 | |
| SCHEMBL3594804 | 0.85 | CYP3A4 (0.36) | DDB1CRBNMAP1LC3BCYP3A4CYP2D6 | |
| SCHEMBL2919213 | 0.84 | CYP3A4 (0.39) | DDB1CRBNMAP1LC3BCYP3A4CYP2D6 | |
| SCHEMBL2915694 | 0.84 | CYP3A4 (0.39) | DDB1CRBNMAP1LC3BCYP3A4CYP2D6 | |
| SCHEMBL2918755 | 0.80 | ALDH1A1 (0.41) | DDB1CRBNMAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3583758 | 0.79 | CYP3A4 (0.42) | DDB1CRBNMAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | ZHANG HESHENG | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | CCNH, CBR1, CBR3 | TP53 759/4885CAPN1 2847/4885GAA 4776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.