Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594340 | 1.00 | NPC1 (0.42) | NPC1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL13167677 | 0.91 | NPC1 (0.41) | NPC1KMT2AMEN1ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL2913793 | 0.90 | NPC1 (0.40) | NPC1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL3594804 | 0.88 | CYP3A4 (0.36) | KMT2AMEN1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL3594808 | 0.88 | CYP3A4 (0.36) | KMT2AMEN1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL3588455 | 0.86 | L3MBTL1 (0.36) | KMT2AMEN1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL3588459 | 0.86 | L3MBTL1 (0.36) | KMT2AMEN1ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL13167690 | 0.86 | PSMB8 (0.42) | NPC1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL3590346 | 0.86 | PSMB8 (0.42) | NPC1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL3584232 | 0.85 | CYP3A4 (0.36) | KMT2AMEN1ALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | ZHANG HESHENG | 2010-09-23 | — | — | US | claimed |
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | ZHANG HESHENG | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240651-A1 | WATER-SOLUBLE THALIDOMIDE DERIVATIVES | CCNH, CBR1, CBR3 | NPC1 3877/4885KMT2A 1947/4885MEN1 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.