Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664937 | 0.84 | CYP1A2 (0.62) | ALDH1A1NPSR1CYP1A2CYP2D6POLB | |
| SCHEMBL1285846 | 0.81 | GAA (0.43) | ALDH1A1NPSR1POLBTP53TDP1 | |
| SCHEMBL31686137 | 0.80 | CHRNB2 (0.49) | ALDH1A1NPSR1CYP1A2CYP2D6POLB | |
| SCHEMBL26645944 | 0.80 | CHRNB2 (0.49) | ALDH1A1NPSR1CYP1A2CYP2D6POLB | |
| SCHEMBL289500 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1CYP1A2CYP2D6TP53TDP1 | |
| SCHEMBL21763578 | 0.80 | ALDH1A1 (0.66) | ALDH1A1NPSR1CYP1A2CYP2D6POLB | |
| SCHEMBL17660287 | 0.79 | CYP1A2 (0.69) | ALDH1A1NPSR1CYP1A2CYP2D6POLB | |
| Hydrochloric Acid SCHEMBL2811924 | 0.79 | SMN1; SMN2 (0.47) | ALDH1A1CYP1A2CYP2D6TP53TDP1 | |
| Hydrochloric Acid SCHEMBL15848241 | 0.78 | CYP1A2 (0.67) | ALDH1A1NPSR1CYP1A2CYP2D6POLB | |
| SCHEMBL1037867 | 0.77 | CYP1A2 (0.77) | ALDH1A1NPSR1CYP1A2CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210688-A1 | Novel Benzothiazolone Derivatives | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | US | disclosed |
| US-7709511-B2 | Benzothiazolone derivatives | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080300275-A1 | Novel Benzothiazolone Derivatives | ASTRAZENECA AB (SE) | 2008-12-04 | — | — | US | disclosed |
| EP-1915354-A1 | NOVEL BENZOTHIAZOLONE DERIVATIVES | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007018461-A1 | NOVEL BENZOTHIAZOLONE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300275-A1 | Novel Benzothiazolone Derivatives | NR0B1, RB1, CCND1 | ALDH1A1 233/4885NPSR1 531/4885CYP1A2 481/4885 |
| US-20100210688-A1 | Novel Benzothiazolone Derivatives | NR0B1, RB1, CCND1 | ALDH1A1 233/4885NPSR1 531/4885CYP1A2 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.