Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.89 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.89 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.89 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2550652 | 0.94 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL30011624 | 0.94 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3250714 | 0.93 | ADORA2B (0.91) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3246972 | 0.92 | ADORA2B (0.87) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3243532 | 0.92 | ADORA2B (0.95) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3246200 | 0.91 | ADORA2B (0.94) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3247031 | 0.91 | ADORA2B (0.85) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3243279 | 0.90 | ADORA2B (0.91) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL7244592 | 0.90 | ADORA2B (0.80) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 | |
| SCHEMBL3246050 | 0.89 | ADORA2B (0.91) | ADORA2BADORA2AADORA1ADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645754-B2 | Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use | OSI PHARMACEUTICALS, INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20080261943-A1 | PYRROLOPYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261943-A1 | PYRROLOPYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | NR0B2, NR0B1, ADORA2B | ADORA2B 3/4885ADORA2A 6/4885ADORA1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.