Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17818418 | 0.94 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2LMNAHSD17B10MEN1 | |
| SCHEMBL713966 | 0.86 | — | — | |
| SCHEMBL10212053 | 0.84 | — | — | |
| SCHEMBL12192684 | 0.83 | LMNA (0.52) | ALDH1A1SMN1; SMN2LMNAHSD17B10MEN1 | |
| SCHEMBL14779101 | 0.82 | — | — | |
| Iodide SCHEMBL8822895 | 0.82 | — | — | |
| SCHEMBL18079303 | 0.81 | CYP4F2 (0.31) | — | |
| SCHEMBL11574155 | 0.81 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL879924 | 0.80 | — | — | |
| SCHEMBL14778009 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557842-B2 | Cocaine analogs and methods of preparation and uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2013-10-15 | — | — | US | disclosed |
| US-20120329828-A1 | Cocaine Analogs and Methods of Preparation and Uses Thereof | NEW YORK UNIVERSITY (US) | 2012-12-27 | — | — | US | disclosed |
| WO-2012009263-A1 | COCAINE ANALOGS AND METHODS OF PREPARATION AND USES THEREOF | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329828-A1 | Cocaine Analogs and Methods of Preparation and Uses Thereof | CES2, CNR1, CNR2 | ALDH1A1 1582/4885SMN1; SMN2 1453/4885LMNA 1042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.