Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591681 | 1.00 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3591685 | 1.00 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3591683 | 1.00 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL13544270 | 0.92 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3586361 | 0.90 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL13544160 | 0.90 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1TRPV1 | |
| SCHEMBL3586358 | 0.90 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3586353 | 0.90 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL3586349 | 0.90 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL5360914 | 0.87 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | TRPV1, TRPA1, TRPV2 | NPC1 879/4885RAB9A 2452/4885SMN1; SMN2 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.