Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555720 | 0.93 | CREBBP (0.64) | CREBBPLMNAHTTMITFALDH1A1 | |
| SCHEMBL14272018 | 0.84 | CREBBP (0.75) | CREBBPLMNAHTTMITFALDH1A1 | |
| SCHEMBL1100436 | 0.77 | CREBBP (0.64) | CREBBPLMNAHTTMITFALDH1A1 | |
| SCHEMBL3608159 | 0.77 | CHEK1 (0.48) | CREBBPCYP3A4L3MBTL1CHEK1AURKA | |
| SCHEMBL12499174 | 0.75 | CREBBP (0.45) | CREBBPALDH1A1CYP3A4CHEK1AURKA | |
| SCHEMBL13462503 | 0.74 | CREBBP (0.44) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL15491013 | 0.72 | CREBBP (0.42) | CREBBPALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11485102 | 0.70 | CREBBP (0.56) | CREBBPLMNAHTTMITFALDH1A1 | |
| SCHEMBL30861109 | 0.70 | VCAM1 (0.38) | CREBBPLMNAHTTMITFALDH1A1 | |
| SCHEMBL27227867 | 0.70 | VCAM1 (0.38) | CREBBPLMNAHTTMITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897550-A2 | Prodrugs of Excitatory Amino Acids | Eli Lilly & Company (US) | 2008-03-12 | — | — | EP | claimed |
| US-20050222231-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY (US) | 2005-10-06 | — | — | US | claimed |
| US-20100063066-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2010-03-11 | — | — | US | disclosed |
| US-20100063066-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2010-03-11 | — | — | US | disclosed |
| US-7671082-B2 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY (US) | 2010-03-02 | — | — | US | disclosed |
| EP-2057168-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| US-7371872-B2 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY (US) | 2008-05-13 | — | — | US | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063066-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | CREBBP 424/4885LMNA 2021/4885HTT 4702/4885 |
| US-20050222231-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A1, SLC1A3 | CREBBP 3432/4885LMNA 4220/4885HTT 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.