Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3592818 | 0.93 | CREBBP (0.73) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL3608159 | 0.87 | CHEK1 (0.48) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL14272018 | 0.78 | CREBBP (0.75) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL3603944 | 0.72 | IKBKE (0.49) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL1100436 | 0.71 | CREBBP (0.64) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL12499174 | 0.70 | CREBBP (0.45) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL13462503 | 0.69 | CREBBP (0.44) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL15491013 | 0.67 | CREBBP (0.42) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL11485102 | 0.65 | CREBBP (0.56) | CREBBPCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL30861109 | 0.65 | VCAM1 (0.38) | CREBBPALDH1A1CYP3A4MITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057168-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008028141-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2008-03-06 | — | — | WO | disclosed |