SCHEMBL3592848

SCHEMBL3592848

CC[SiH](OC)OCC1CO1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 8/20 0.39
TDP1 Q9NUW8 2/20 0.37
TSHR P16473 4/20 0.36
MAPK1 P28482 1/20 0.36
GLA P06280 1/20 0.32
TP53 P04637 2/20 0.30
MAPT P10636 2/20 0.30
HPGD P15428 2/20 0.30
MEN1 O00255 1/20 0.30
CYP1A2 P05177 1/20 0.30
KMT2A Q03164 1/20 0.30
PPARG P37231 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1565347 0.84 SMN1; SMN2 (0.41) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
SCHEMBL28645775 0.76 ALDH1A1 (0.43) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
SCHEMBL2232369 0.72 TSHR (0.47) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
SCHEMBL1564891 0.72 SMN1; SMN2 (0.41) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
SCHEMBL11710041 0.71 SMN1; SMN2 (0.43) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
SCHEMBL11624164 0.71 SMN1; SMN2 (0.44) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
Water SCHEMBL28100389 0.71 SMN1; SMN2 (0.48) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1
SCHEMBL2672371 0.70
SCHEMBL3741955 0.70
SCHEMBL6770126 0.70 SMN1; SMN2 (0.36) SMN1; SMN2ALDH1A1TDP1TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7692013-B2 Method for separation and purification of hydrocodone by preparative chromatography MALLINKRODT INC. (US) 2010-04-06 US claimed
EP-1682505-B1 INDUSTRIAL METHOD FOR SEPARATION AND PURIFICATION OF FENTANYL BY REVERSE PHASE PREPARATIVE CHROMATOGRAPHY MALLINCKRODT INC (US) 2008-12-24 EP claimed
EP-0470247-B1 REVERSED PHASE CHROMATOGRAPHIC PROCESS MALLINCKRODT INC (US) 1997-04-16 EP claimed
US-5204005-A Decolorization, separation, purification of water-soluble nonionic contrast media compounds; removing nonionic impurities MALLINCKRODT, INC. (US) 1993-04-20 US claimed
WO-1991012868-A1 REVERSED PHASE CHROMATOGRAPHIC PROCESS MALLINCKRODT, INC. (US) 1991-09-05 WO claimed
EP-1682505-B1 INDUSTRIAL METHOD FOR SEPARATION AND PURIFICATION OF FENTANYL BY REVERSE PHASE PREPARATIVE CHROMATOGRAPHY MALLINCKRODT INC (US) 2008-12-24 EP disclosed
EP-0470247-B1 REVERSED PHASE CHROMATOGRAPHIC PROCESS MALLINCKRODT INC (US) 1997-04-16 EP disclosed
WO-1991012868-A1 REVERSED PHASE CHROMATOGRAPHIC PROCESS MALLINCKRODT, INC. (US) 1991-09-05 WO disclosed