Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 18/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589906 | 0.87 | P2RX7 (0.62) | P2RX7MAPK14 | |
| SCHEMBL3581901 | 0.82 | P2RX7 (0.76) | P2RX7MAPK14 | |
| SCHEMBL3287833 | 0.80 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3596513 | 0.78 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3590914 | 0.77 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL4699997 | 0.73 | P2RX7 (0.67) | P2RX7MAPK14 | |
| SCHEMBL3288626 | 0.71 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL3287817 | 0.69 | P2RX7 (0.78) | P2RX7 | |
| SCHEMBL3290316 | 0.68 | P2RX7 (1.00) | P2RX7 | |
| SCHEMBL4755588 | 0.68 | P2RX7 (0.57) | P2RX7MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105842-A1 | P2X7 receptor antagonists and methods of use | ABBVIE INC. | 2007-05-10 | — | — | US | claimed |
| US-7709469-B2 | P2X7 receptor antagonists and methods of use | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070105842-A1 | P2X7 receptor antagonists and methods of use | ABBVIE INC. | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105842-A1 | P2X7 receptor antagonists and methods of use | P2RX7, P2RX1, P2RX3 | P2RX7 1/4885MAPK14 2541/4885LMNA 2778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.