Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | GCK | P35557 | 5/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | ARAF | P10398 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3601411 | 0.86 | KMT2A (0.59) | GCKKCNH2USP2KMT2AALDH1A1 | |
| SCHEMBL2652813 | 0.84 | GCK (0.44) | SMN1; SMN2GCKKCNH2USP2KMT2A | |
| SCHEMBL9072522 | 0.84 | USP2 (0.48) | SMN1; SMN2GCKKCNH2BRAFHDAC1 | |
| SCHEMBL1261462 | 0.83 | GCK (0.57) | SMN1; SMN2TSHRGCKUSP2KMT2A | |
| SCHEMBL3599562 | 0.82 | GCK (0.42) | GCKKCNH2USP2KMT2AALDH1A1 | |
| SCHEMBL3610668 | 0.82 | GCK (0.42) | SMN1; SMN2TSHRHTTGCKKCNH2 | |
| SCHEMBL3599003 | 0.82 | ALDH1A3 (0.54) | GCKKCNH2USP2KMT2AALDH1A1 | |
| SCHEMBL1107694 | 0.81 | CA1 (0.50) | TSHRHTTUSP2KMT2AKDM4E | |
| SCHEMBL2657569 | 0.81 | GCK (0.43) | GCKKCNH2USP2KMT2AALDH1A1 | |
| SCHEMBL3599838 | 0.81 | LOXL2 (0.54) | GCKUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754743-B2 | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | MSD K.K. (JP) | 2009-01-15 | — | — | US | disclosed |
| US-7432287-B2 | Heteroarylcarbamoylbenzene derivative | BANYU PHARMECEUTICAL CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | MSD K.K. (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1600442-A1 | HETEROARYLCARBAMOYLBENZENE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | GCK, GCKR, KHK | HPGD 2765/4885SMN1; SMN2 4432/4885TSHR 2079/4885 |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | GCK, GCKR, GALK1 | HPGD 1277/4885SMN1; SMN2 4329/4885TSHR 3647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.